Fresh analysis suggests that patients who stop using blockbuster slimming jabs like semaglutide or tirzepatide may regain reduced body mass far faster than those who halt traditional lifestyle regimens.
Research printed in a prominent health publication points out that while overweight individuals frequently drop a large proportion of their body weight while using the jabs, the mass is regained at an estimated rate of 0.8 kg per month upon discontinuation.
"People buying these treatments need to be aware of the danger of fast rebound weight gain when the medication ends," cautioned lead investigator Dr. Susan Jebb.
This pace of recovery implies a return to starting mass within about 18 months.
Weighing Treatments
The research, which examined dozens of studies involving over 9,000 of participants, compared the effects of the injectable medications with conventional dieting.
The team point out that people who shed pounds through diet and exercise generally see a slower creep back—around 100 grams monthly—once they finish.
Understanding the Rapid Regain
Doctors suggest the way of the injections explains the amplified weight return.
GLP-1 drugs mimic a natural hormone called glucagon-like peptide-1, which controls appetite.
"Long-term administration of the hormone levels far above than normal could lead to the body to generate a reduced amount of its endogenous GLP-1, and could reduce responsiveness to its actions," said Dr. Adam Collins, a dietetics researcher.
"Withdrawal of this GLP-1 'fix' results in hunger is no longer kept in check, making overeating much more probable."
A Chronic Condition?
Health authorities suggest the injections for individuals with obesity-related health risks, accompanied by recommended diet and exercise modifications.
Many experts say that, given the significant potential of relapse, the treatment should be considered long-term.
This opinion is echoed by drug manufacturers, who note that the findings "emphasize the long-term character of excess weight," comparing it to managing diseases like diabetes.
Patient Experiences
People who have stopped the jabs report a sudden return of cravings.
"It was like a trigger activating and you become ravenous," said an individual.
This challenge is exacerbated if users have not developed permanent dietary or behavioural modifications during treatment.
Growing Use
Survey data suggest that a significant number of people in the UK have used weight-loss jabs in the last 12 months, with desire continuing to grow.
- Adoption is more common among women compared to males.
- The 40s and 50s age group shows the highest level of interest.
- Many access the drugs through private prescriptions rather than public health services.
In conclusion, researchers emphasize that while these medications are potent tools for weight loss, they are not a standalone cure and maintained weight loss relies on ongoing lifestyle management.
